HudsonAlpha Faculty Investigator Richard M. Myers, PhD, and his lab study the human genome to understand how changes in gene expression and allelic variation contribute to human health and disease, as well as to basic biological processes. 

Myers’s group develops and applies innovative technologies and high-throughput next-generation sequencing technology to identify, characterize, and understand gene regulatory systems. By first understanding gene expression and regulatory systems in a healthy state, his group then studies how these mechanisms are altered during the development and progression of human disease.

A major goal of the Myers lab is to use high-throughput genomic methods and computational and statistical tools to study clinical and basic biological problems. Researchers in the Myers Lab integrate the data from these different tools to understand how variations in genome sequences and expression are involved in human health and disease, particularly in neurodegenerative diseases and neuropsychiatric disorders.

The lab currently focuses its efforts on the following areas:

  • Understanding how human gene expression is regulated in a wide variety of cell types
  • Applying functional genomics tools, including genome-wide studies of transcription factors and cis-acting elements, to understand basic mechanisms and the role of these components in diseases of the nervous system
  • Correlating changes in gene expression and transcription factor binding with genetic variation in cis- and trans-acting components of gene expression 
  • Developing and applying technologies to identify biomarkers for disease diagnosis and treatment
  • Identifying new gene candidates and risk factors for diseases of the nervous system 

Recent News

February 2, 2023
HudsonAlpha researchers identified transcription factors that may be involved in altered gene expression seen in Alzheimer’s disease. In a recent study, the team, led by Lindsay Rizzardi, PhD from Dr. Rick Myers’ lab, used sin...
December 30, 2022
Researchers at the HudsonAlpha Institute for Biotechnology recently published a paper in the American Journal of Human Genetics associating genetic variation in a gene called ZMYM3 with neurodevelopmental disorders. The kicker? Th...
February 10, 2022
As HudsonAlpha Institute for Biotechnology continues its rapid economic growth and advancements in genomics and life science research, the HudsonAlpha board of directors announced today the expansion of its executive leadership te...
Load More