- Cancer research
- Gulf War Illness and Toxicogenomics
- Neurological Disorders
- Nuclear Receptors in Gene Regulation
Information for the science community can be found by going to the personal webpage Myers Lab.
New, robust methodology is side benefit
HUNTSVILLE, Ala. --Whether or not a gene is expressed, that is, whether it is turned on or turned off, is in part controlled by a group of proteins called transcription factors. Scientists in the Myers lab at the HudsonAlpha Institute recently published results of a basic research project undertaken to better understand mechanisms that determine cell type-specific transcription factor binding.
HudsonAlpha and UAB researchers work to identify optimal treatments for the most common form of breast cancer
Komen funds collaborative effort using tumor genomics to identify effective treatments
HUNTSVILLE, Ala. – The most commonly diagnosed form of breast cancer, termed estrogen receptor positive or ER+, accounts for the largest percentage of breast cancer deaths each year. Research by scientists at the HudsonAlpha Institute for Biotechnology and the University of Alabama at Birmingham Comprehensive Cancer Center aims to provide physicians a more targeted approach to treating ER+ breast cancer.
NIH study seeks genetic links to answer the “Why?” of unexplained disorders
HUNTSVILLE, Ala -- Even in the absence of a ready solution, knowing why a child faces physical, emotional and intellectual challenges is helpful to physicians and families. Researchers at the HudsonAlpha Institute for Biotechnology are using high throughput genomic sequencing to meet major diagnostic needs for childhood genetic disorders through a multi-year grant potentially totaling more than $7.6 million from the National Institutes of Health.
A collaborative effort between Epicentre and the HudsonAlpha Institute for Biotechnology resulted in the development of two novel transposon-based methods for RNA-Seq library preparation. The technique, called Tn-RNA-Seq, can use double-stranded cDNA created from rRNA-depleted RNA to prepare an Illumina sequencing library using only two enzymatic reactions. The researchers generated high-quality RNA-Seq libraries from as little as 10 pg of mRNA (~1 ng of total RNA) with this approach.
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HUNTSVILLE, Ala. - DNA data from hundreds of North Alabama children and their parents will soon be part of a major new genetic study of childhood diseases led by Huntsville's HudsonAlpha Institute for Biotechnology and including the University of Alabama in Birmingham. The National Institutes of Health announced a $7.6 million research grant Tuesday to the non-profit institute for the study.
HudsonAlpha Institute contributes to largest cancer genome study from NIH consortium
HUNTSVILLE, Ala - Integrating 500 patient samples and multiple genomic technologies, The Cancer Genome Atlas Research Network has, according to a release by the National Institutes of Health, assembled the most comprehensive view of cancer genes for any cancer type to date. The analyses of data are reported in the June 30 issue of Nature.
HudsonAlpha is part of international team releasing massive dataset
HUNTSVILLE, Ala. - The international team of the ENCODE, or Encyclopedia Of DNA Elements project, has created an overview of its ongoing large-scale efforts to interpret the human genome sequence.
By Monica Heger
In an example of how sequencing can be used to study not onlythe genetic underpinnings of disease but also the genetics of drug response, researchers at the HudsonAlpha Institute for Biotechnology have teamed up with clinicians at the University of Alabama, Birmingham, to perform transcriptome sequencing on 200 brain tissue samples, from patients and healthy individuals, as well as whole-exome sequencing on the genomes of 100 Parkinson's patients enrolled in a clinical trial for the drug levodopa.
Newly announced HudsonAlpha resident associate company Kailos Genetics and Dr. K-T Varley of Myers Lab are featured in a Fall 2010 Technology Alabama article. The full story is attached as a PDF.
A gene has been associated with human kidney aging, according to researchers from Stanford University, the National Institute on Aging, the MedStar Research Institute, and the HudsonAlpha Institute for Biotechnology. In work published on October 16 in the open-access journal PLoS Genetics, the investigators, including HudsonAlpha Faculty Investigators Rick Myers and Devin Absher, claim that their approach can be applied to any phenotype of interest to help find other genetic associations.
It is probably a safe bet that genomics would be a slightly different place had Richard Myers pursued his original path. Myers — now president and director of the Hudson-Alpha Institute for Biotechnology in Huntsville, Ala. — began his academic career as a sociology major at the University of Alabama in the mid-1970s. But halfway through, he ended up in a chemistry class that captured his interest and caused him to drop the softer science cold. And it's a good thing, too, because Myers went on to play a major role in the Human Genome Project, among many other large-scale collaborations. From 1993 until 2008, Myers was a professor in the department of genetics at Stanford University School of Medicine, where he also directed the Stanford Human Genome Center. In fact, Myers and his genome center contributed roughly 11 percent of the human sequence — chromosomes 5, 16, and 19.