Let us help you achieve your strain optimization goals

Our Pipeline & Process

Microorganisms are increasingly used as cellular factories for biosynthesizing drugs and therapeutic proteins, sustainable alternatives to animal products, and other commodities like fuel, fragrances, and flavorings. Engineering microbes to produce specific biomolecules is challenging, expensive, and often time-consuming. Some of the challenges in biomanufacturing include low expression, enzyme degradation, misfolding, secretion issues, and inactivity.

Iterative genome engineering cycles can help you reach your strain improvement goals quicker. The GEL pipeline can facilitate genome-wide engineering, targeted pathway construction and optimization, enzyme engineering and evolution, the extension of substrate scope, and metabolic robustness improvement.

Using the Onyx Platform® as the backbone for its pipeline, the HudsonAlpha Genome Engineering Lab (GEL) can help you achieve your strain optimization and engineering goals. We offer our expertise throughout the engineering process– from rational genome edit design to the delivery of a pool of edited cells specialized to meet your synthetic biology goals.

Prior to genome editing, our experts can sequence your microbial strain, engineer in heterologous genes, characterize your custom strain for genome engineering and rationally design the first pool of genome-wide edits. The GEL pipeline offers several services after the Onyx Platform has produced pools of edited cells, including Illumina sequencing and barcode analysis, pool outgrowth, robotic colony picking, and whole genome sequencing to identify edits.