Greg Cooper’s Lab

Greg Cooper’s lab focuses on the analytical challenges and opportunities presented by affordable, routine sequencing of human genomes. We conduct research at the interface of human genetics, genomics and molecular evolution, motivated by the long-term goal of understanding how our genomes shape our lives.

We are interested in the structures, functions and evolutionary histories of human genomes, with an emphasis on applying genomic approaches to study human disease.  Our research includes computational analyses of the relationship between mammalian evolution and modern-day diversity, functional analysis of genetic contributions to gene expression and the identification and characterization of deleterious mutations that play causal roles in human disease.  We have ongoing projects related to:

  • Applications of comparative genomics to association studies
  • Exome and genome sequencing analysis of human disease
  • Identification and characterization of expression quantitative trait loci
  • Analysis of copy-number variable loci in severe pediatric disease


Greg Cooper’s lab is supported in part by the National Institutes of Health (Award Numbers R01MH110472, U01HG007301, P50GM115279, R01CA197139, and U24HD090744) and the State of Alabama. The content of this website is solely the responsibility of the authors and does not necessarily represent the official views of the sponsors.

Lab Members


Greg Cooper

Faculty Investigator

Michelle Amaral

Senior Scientist

Kevin Bowling

Senior Scientist
Stephanie Felker, PhD

Stephanie Felker

Graduate Student
Candice Short

Candice Finnila

Clinical Project Manager

Susan Hiatt

Senior Scientist

Don Latner

Senior Scientist

James Lawlor

Jr. Computational Biologist

Michelle Thompson

Senior Scientist