Jane Grimwood, Ph.D.
Investigator

Dr. Grimwood received her B.Sc. and Ph.D. in microbiology from the University of Leeds in the United Kingdom, followed by postdoctoral training at the University of Oxford, Dartmouth College and the University of San Francisco. Since 2000, she has been a senior scientist at the Stanford Human Genome Center where she and her group were responsible for finishing and performing quality analysis on the 320 million base pairs of human chromosomes 5, 16 and 19, comprising more than 10 percent of the human genome. After the completion of the Human Genome Project, Grimwood continues to lead a group focusing on sequencing, finishing and genome improvement of a wide variety of eukaryotic genomes, including plants, fungi and vertebrates. She joins HudsonAlpha in 2008.

Research interests

• Genome improvement and finishing of eukaryotic organisms
• Cloning systems
• Host/pathogen interactions at the cellular and the genomic levels
• Comparative sequence analysis

Selected publications
Grimwood J, JR Mineo, and LH Kasper (1996) Attachment of Toxoplasma gondii to host cells is cell-cycle dependent. Infection and Immunity 64: 4099-4104.

Kalman S, W Mitchell, R Marathe, C Lammel J Fan, RW Hyman, L Olinger, J Grimwood, RW Davis and RS Stephens (1999) Comparative genomes of Chlamydia pneumoniae and C.trachomatis. Nature Genetics 21: 385-389.

Grimwood J, L Olinger and RS Stephens (2001) Expression of Chlamydia pneumoniae polymorphic membrane protein family genes. Infection and Immunity 69: 2283-2389.

Wu Q, T Zhang, JF Cheng, Y Kim, J Grimwood, J Schmutz, M Dickson, J Noonan, M Zhang, RM Myers and T Maniatis (2001) Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. Genome Research 11: 389-404.

Grimwood, J., Gordon, L.A., Terry, A., Olsen, A., Schmutz, J.,..., Branscomb, E., Rokhsar, D. S., Myers, R. M., Rubin, E. M., and Lucas, S. M. (2004) The DNA sequence and biology of human chromosome 19. Nature. 428: 529-535.

Noonan, J. P., Grimwood, J., Danke, J., Schmutz, J., Dickson, M., Amemiya, C. T. and Myers, R. M. (2004). Coelacanth genome sequence reveals the evolutionary history of vertebrate genes. Genome Res. 12: 2397-2405.

Schmutz, J., Wheeler, J., Grimwood, J., Dickson, M., ..., and Myers, R. M. (2004) Quality assessment of the human genome sequence. Nature. 429: 365-368.

Colosimo, P. F., Hosemann, K. E., Balabhadra, S., Villareal, G., Dickson, M., Grimwood, J., Schmutz, J., Myers, R. M., Schluter, D. and Kingsley, D. M. (2005) Widespread parallel evolution of stickleback armor plates determined by ancestral genetic variation in Ectodysplasin. Science. 307: 1928-1933.
Jeffries TW, Grigoriev IV, Grimwood J, Laplaza JM, Aerts A, Salamov A, Schmutz J, Lindquist E, Dehal P, Shapiro H, Jin YS, Passoth V, Richardson PM. (2007) Genome sequence of the lignocellulose-bioconverting and xylose-fermenting yeast Pichia stipitis, Nature Biotechnology 25: 319-326.

Palenik B, Grimwood J, Aerts A ….Schmutz J, Rokhsar D, Van de Peer Y, Moreau H, Grigoriev IV (2007). The tiny eukaryote Ostreococcus provides genomic insights into the paradox of plankton speciation. PNAS 104: 7705-7710.