Faculty investigator, president and director
Richard Myers, Ph.D., received his B.S. from the University of Alabama in Tuscaloosa in 1977, his Ph.D. from the University of California at Berkeley and performed postdoctoral work at Harvard University. His first faculty position was at UC San Francisco in 1986, then Stanford University in 1993. At Stanford, Myers served as chair of the department of genetics and director of the Stanford Human Genome Center until he moved to HudsonAlpha in July 2008.
Myers’ research program is focused on human genetics and genomics. Work in his laboratory has led to the identification of genes involved in inherited diseases, and his genome center contributed more than 10 percent of the data for the public Human Genome Project. His lab continues to use genomics tools and genetics to understand how genes interacting with the environment contribute to human diseases and other traits.
Current research areas in the Myers Lab include:
• Applying high-throughput genomic assays, including RNA-seq, ChIP-seq and DNA methylation assays to the study of breast, kidney, prostate and pancreatic cancers. The Myers Lab identifies signatures of cancer that lead to understanding of disease progression and help determine optimal treatment regiments.
• The development of ChIP-seq to identify binding sites in dozens of different cell lines for many transcription factors. As part of the ENCODE Project, these data are integrated with genotyping, RNA-seq and methylation assays, providing a powerful tool for a comprehensive interpretation of the human genome.
• Using next-generation sequencing techniques to understand the role of methylation and gene expression changes in the development of psychiatric and neurodegenerative disorders.
Selected recent publications
Li, J. Z., and Absher, D. M., et al. (2008). Worldwide human relationships inferred from genome-wide patterns of variation. Science. 319: 1100-1104.
Kobayashi, Y. et al. DNA methylation profiling reveals novel biomarkers and important roles for DNA methyltransferases in prostate cancer. (2011). Genome Res. 21: 1017–1027.
ENCODE Project Consortium. (2011). A user’s guide to the Encyclopedia of DNA Elements (ENCODE). PLoS Biol. 9: e1001046.
Gertz, J. et al. (2011). Analysis of DNA methylation in a three-generation family reveals widespread genetic influence on epigenetic regulation. PLoS Genet. 7, e1002228.
Reddy, T. E. et al. (2012). Effects of sequence variation on differential allelic transcription factor occupancy and gene expression. Genome Res. 22: 860–869. See Research Highlight in Nature Reviews Genetics. doi:10.1038/nrg3219.
The ENCODE Project Consortium. (2012). An Integrated Encyclopedia of DNA Elements in the Human Genome. Nature. 489: 57–74.